From the pitcher who got his groove back to the doctor who's bringing Pac Heights to Bayview to the gamer who wants to fix reality itself—these are the 20 locals putting the spotlight on SF and lighting a fire under the rest of us.

Mike Krieger and Kevin Systrom, Instagram foundersMaia Kayser, Rango animator
Ryan Vogelsong, San Francisco Giants starting pitcher Anthony Myint, restaurateur and Corey Lee, Benu chef-owner
Lauren Gunderson, playwright and Nathan Wolfe, epidemiologistMatthew Zapruder, Poet and 2011 Guggenheim fellow
Nadine Burke Harris, Center for Youth Wellness CEO and Bayview Child Health Center founding physician Russ Angold and Nathan Harding, eLEGS inventors
Beth Spotswood, Political satirist and SFGate columnist Ruth Laskey, Visual artist
Jane Henzerling, Mission Preparatory School founding principal Stuart Schuffman, Broke-Ass Stuart blogger
Benny Gold, Graphic designer and owner of Benny Gold Lauren Geremia, Geremia Design principal
Ross Mirkarimi, District 5 supervisor and candidate for sheriffEmily Chang, Bloomberg West cohost
Christine Schmidt, Yellow Owl Workshop founderMatt Cohen, Off the Grid owner and operator
Jane McGonigal, Social Chocolate cofounder and creative director Minna Choi, Magik*Magik Orchestra founding creative director
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